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Yomogida, Kentaro; Bigley, Tarin M; Trsan, Tihana; Gilfillan, Susan; Cella, Marina; Yokoyama, Wayne M; Egawa, Takeshi; Colonna, Marco
Proceedings of the National Academy of Sciences - PNAS, 12/2021, Letnik: 118, Številka: 50Journal Article
Identification of type 1 innate lymphoid cells (ILC1s) has been problematic. The transcription factor Hobit encoded by has been proposed as a major driver of ILC1 programs. Using reporter mice, we showed that correlation of Hobit expression with ILC1s is tissue- and context-dependent. In liver and intestinal mucosa, expression correlated well with ILC1s; in salivary glands, was coexpressed with the natural killer (NK) master transcription factors Eomes and TCF1 in a unique cell population, which we call ILC1-like NK cells; during viral infection, was induced in conventional NK cells of spleen and liver. The impact of deletion on ILC1s and NK cells was also multifaceted, including a marked decrease in granzyme- and interferon-gamma (IFNγ)-producing ILC1s in the liver, slightly fewer ILC1s and more Eomes TCF1 ILC1-like NK cells in salivary glands, and only reduced production of granzyme B by ILC1 in the intestinal mucosa. NK cell-mediated control of viral infection was unaffected. We conclude that Hobit has two major impacts on ILC1s: It sustains liver ILC1 numbers, while promoting ILC1 functional maturation in other tissues by controlling TCF1, Eomes, and granzyme expression.
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in: SICRIS
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