E-viri
Recenzirano
Odprti dostop
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Wang, Yi; Chiang, I-Ling; Ohara, Takahiro E.; Fujii, Satoru; Cheng, Jiye; Muegge, Brian D.; Ver Heul, Aaron; Han, Nathan D.; Lu, Qiuhe; Xiong, Shanshan; Chen, Feidi; Lai, Chin-Wen; Janova, Hana; Wu, Renee; Whitehurst, Charles E.; VanDussen, Kelli L.; Liu, Ta-Chiang; Gordon, Jeffrey I.; Sibley, L. David; Stappenbeck, Thaddeus S.
Cell, 11/2019, Letnik: 179, Številka: 5Journal Article
The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. The responsive stem cell that mediates this process is unclear, in part because of a lack of in vitro models that recapitulate key epithelial changes that occur in vivo during damage and repair. Here, we identify a Hopx+ colitis-associated regenerative stem cell (CARSC) population that functionally contributes to mucosal repair in mouse models of colitis. Hopx+ CARSCs, enriched for fetal-like markers, transiently arose from hypertrophic crypts known to facilitate regeneration. Importantly, we established a long-term, self-organizing two-dimensional (2D) epithelial monolayer system to model the regenerative properties and responses of Hopx+ CARSCs. This system can reenact the “homeostasis-injury-regeneration” cycles of epithelial alterations that occur in vivo. Using this system, we found that hypoxia and endoplasmic reticulum stress, insults commonly present in inflammatory bowel diseases, mediated the cyclic switch of cellular status in this process. Display omitted •Identify a regenerative stem cell population in colitis-associated regeneration•A long-term 2D culture to reenact the crypt homeostasis-injury-regeneration cycles•Oxygen tension serves as a switch in injury and regeneration in vivo and in vitro An Lgr5+-independent population of stem cells maintains homeostasis in the colon and is associated with colitis-associated regeneration.
Avtor
Vnos na polico
Trajna povezava
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Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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