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Wang, Haopeng; Kadlecek, Theresa A; Au-Yeung, Byron B; Goodfellow, Hanna E Sjölin; Hsu, Lih-Yun; Freedman, Tanya S; Weiss, Arthur
Cold Spring Harbor perspectives in biology, 05/2010, Letnik: 2, Številka: 5Journal Article
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.
