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Kuchenbaecker, Karoline; Telkar, Nikita; Reiker, Theresa; Walters, Robin G; Lin, Kuang; Eriksson, Anders; Gurdasani, Deepti; Gilly, Arthur; Southam, Lorraine; Tsafantakis, Emmanouil; Karaleftheri, Maria; Seeley, Janet; Kamali, Anatoli; Asiki, Gershim; Millwood, Iona Y; Holmes, Michael; Du, Huaidong; Guo, Yu; Kumari, Meena; Dedoussis, George; Li, Liming; Chen, Zhengming; Sandhu, Manjinder S; Zeggini, Eleftheria
Nature communications, 09/2019, Letnik: 10, Številka: 1Journal Article
Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r = 0.23-0.28, p < 1.9 × 10 ). Overall, there is evidence of reproducibility for ~75% of the major lipid loci from European discovery studies, except triglyceride loci in the Ugandan samples (10% of loci). Individual transferable loci are identified using trans-ethnic colocalization. Ten of fourteen loci not transferable to the Ugandan population have pleiotropic associations with BMI in Europeans; none of the transferable loci do. The non-transferable loci might affect lipids by modifying food intake in environments rich in certain nutrients, which suggests a potential role for gene-environment interactions.
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in: SICRIS
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