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Yu, Zhengze; Zhou, Ping; Pan, Wei; Li, Na; Tang, Bo
Nature communications, 11/2018, Letnik: 9, Številka: 1Journal Article
Photodynamic therapy (PDT) is ineffective against deeply seated metastatic tumors due to poor penetration of the excitation light. Herein, we developed a biomimetic nanoreactor (bio-NR) to achieve synergistic chemiexcited photodynamic-starvation therapy against tumor metastasis. Photosensitizers on the hollow mesoporous silica nanoparticles (HMSNs) are excited by chemical energy in situ of the deep metastatic tumor to generate singlet oxygen ( O ) for PDT, and glucose oxidase (GOx) catalyzes glucose into hydrogen peroxide (H O ). Remarkably, this process not only blocks the nutrient supply for starvation therapy but also provides H O to synergistically enhance PDT. Cancer cell membrane coating endows the nanoparticle with biological properties of homologous adhesion and immune escape. Thus, bio-NRs can effectively convert the glucose into O in metastatic tumors. The excellent therapeutic effects of bio-NRs in vitro and in vivo indicate their great potential for cancer metastasis therapy.
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