E-viri
PDF
Recenzirano
Odprti dostop
-
Horng, Tiffany
Trends in immunology, 06/2014, Letnik: 35, Številka: 6Journal Article
Highlights • The NLRP3 inflammasome is activated by mitochondrial destabilization and dysfunction. • Recognition of mtDNA and externalized cardiolipin by the NLRP3 inflammasome may be direct. • Ca2+ is mobilized in many settings of NLRP3 inflammasome activation. • Intercepting Ca2+ mobilization inhibits inflammasome activation. • Ca2+ may trigger mitochondrial destabilization leading to NLRP3 inflammasome activation.
