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Niemeijer, A N; Leung, D; Huisman, M C; Bahce, I; Hoekstra, O S; van Dongen, G A M S; Boellaard, R; Du, S; Hayes, W; Smith, R; Windhorst, A D; Hendrikse, N H; Poot, A; Vugts, D J; Thunnissen, E; Morin, P; Lipovsek, D; Donnelly, D J; Bonacorsi, S J; Velasquez, L M; de Gruijl, T D; Smit, E F; de Langen, A J
Nature communications, 11/2018, Letnik: 9, Številka: 1Journal Article
PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.
