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Krejcová, Lane Viana; Bento-Torres, João; Diniz, Daniel Guerreiro; Pereira, Jr, Antonio; Batista-de-Oliveira, Manuella; de Morais, Andreia Albuquerque Cunha Lopes; Mendes-da-Silva, Rosângela Figueiredo; Abadie-Guedes, Ricardo; Dos Santos, Ângela Amâncio; Lima, Denise Sandrelly; Guedes, Rubem Carlos Araujo; Picanço-Diniz, Cristovam Wanderley
Brain sciences, 05/2024, Letnik: 14, Številka: 5Journal Article
This study explores the multifaceted influence of litter size, maternal care, exercise, and aging on rats' neurobehavioral plasticity and dentate gyrus microglia dynamics. Body weight evolution revealed a progressive increase until maturity, followed by a decline during aging, with larger litters exhibiting lower weights initially. Notably, exercised rats from smaller litters displayed higher body weights during the mature and aged stages. The dentate gyrus volumes showed no significant differences among groups, except for aged sedentary rats from smaller litters, which exhibited a reduction. Maternal care varied significantly based on litter size, with large litter dams showing lower frequencies of caregiving behaviors. Behavioral assays highlighted the detrimental impact of a sedentary lifestyle and reduced maternal care/large litters on spatial memory, mitigated by exercise in aged rats from smaller litters. The microglial dynamics in the layers of dentate gyrus revealed age-related changes modulated by litter size and exercise. Exercise interventions mitigated microgliosis associated with aging, particularly in aged rats. These findings underscore the complex interplay between early-life experiences, exercise, microglial dynamics, and neurobehavioral outcomes during aging.
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