Purpose: Two new Staphylococcus aureus vaccines, S. aureus four-antigen (SA4Ag) and three-antigen (SA3Ag) vaccines, have good immunogenicity and tolerance. However, the safety of these vaccines is worth exploring. Here, we performed a meta-analysis to investigate the safety of SA3Ag and SA4Ag by evaluating systemic and local adverse events. Methods: The Medline, EMBASE, and Cochrane databases were searched for randomized clinical trials confirming the safety of SA4Ag and SA3Ag. Two investigators independently selected suitable trials, assessed trial quality, and extracted data. Results: Three studies comprising a total of 1,148 participants were included in this review. The two S. aureus vaccines did not increase systemic adverse events (relative ratio 1.1 95% confidence interval 0.98, 1.24), but increased the incidence of local adverse events (2.89 2.15, 3.90). However, the incidence of severe local adverse events (4.06 0.78, 21.24) did not rise significantly. Conclusions: SA4Ag and SA3Ag have acceptable safety in adults.