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Goërtz, Yvonne M J; Braamse, Annemarie M J; Spruit, Martijn A; Janssen, Daisy J A; Ebadi, Zjala; Van Herck, Maarten; Burtin, Chris; Peters, Jeannette B; Sprangers, Mirjam A G; Lamers, Femke; Twisk, Jos W R; Thong, Melissa S Y; Vercoulen, Jan H; Geerlings, Suzanne E; Vaes, Anouk W; Beijers, Rosanne J H C G; van Beers, Martijn; Schols, Annemie M W J; Rosmalen, Judith G M; Knoop, Hans
Scientific reports, 10/2021, Letnik: 11, Številka: 1Journal Article
(1) To evaluate the prevalence of severe and chronic fatigue in subjects with and without chronic disease; (2) to assess to which extent multi-morbidity contributes to severe and chronic fatigue; and (3) to identify predisposing and associated factors for severe and chronic fatigue and whether these are disease-specific, trans-diagnostic, or generic. The Dutch Lifelines cohort was used, including 78,363 subjects with (n = 31,039, 53 ± 12 years, 33% male) and without (n = 47,324, 48 ± 12 years, 46% male) ≥ 1 of 23 chronic diseases. Fatigue was assessed with the Checklist Individual Strength-Fatigue. Compared to participants without a chronic disease, a higher proportion of participants with ≥ 1 chronic disease were severely (23% versus 15%, p < 0.001) and chronically (17% versus 10%, p < 0.001) fatigued. The odds of having severe fatigue (OR 95% CI) increased from 1.6 1.5-1.7 with one chronic disease to 5.5 4.5-6.7 with four chronic diseases; for chronic fatigue from 1.5 1.5-1.6 to 4.9 3.9-6.1. Multiple trans-diagnostic predisposing and associated factors of fatigue were found, explaining 26% of variance in fatigue in chronic disease. Severe and chronic fatigue are highly prevalent in chronic diseases. Multi-morbidity increases the odds of having severe and chronic fatigue. Several trans-diagnostic factors were associated with fatigue, providing a rationale for a trans-diagnostic approach.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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