Focal Segmental Glomerulosclerosis (FSGS) is a unique type of long-term renal disease in which there is an indurated invasion of the glomerulus in particular segments picturized in the renal biopsy that terminates into an end-stage kidney dysfunction. Invasive pulmonary aspergillosis (IPA) is difficult diagnose fungal infection, as well as due to its rapid progression can lead to disseminated disease and death within weeks This case outlines the effect of physiotherapy rehabilitation in a case of FSGS with IPA in a 56-year-old man who presented with complaints of breathlessness, cough with expectoration and abdominal pain. Following investigations such as High-Resolution Computed Tomography (HRCT) scan, the patient was diagnosed with IPA for which he was kept under observation following which supervised Physiotherapy Intervention (PI) commenced. The outcome measure was Peak Expiratory Flow Rate (PEFR), whereas the intervention involved Diaphragmatic Breathing Exercises (DBEs), Breath Stacking Technique (BS), Incentive Spirometry (IS), Range of Motion (ROM) exercises, Active Cycle of Breathing Technique (ACBT), Inspiratory Muscle Training (IMT) and ambulation. After two weeks of treatment, there was an improvement in cough frequency, an appreciable change in vital capacity (VC) and a significant increase in PEFR values