Humor research has developed along a trajectory, and branched out in many directions, that were foreseen and stimulated by Paul McGhee. From his initial interest in children’s humor and cognitive development as a graduate student at Ohio State University to his work applying humor in myriad settings, McGhee has broadened our understanding of humor and expanded its horizons. As early as the 1970s, Paul expressed interest in the neuropsychology of humor and laughter and in the evolution of humor in nonhuman primates. The development and validation of the Sense of Humor Scale is an integral part of the 7 Humor Habits Program used effectively to train humor skills. McGhee played an early role in advocating humor and laughter as a learnable tool in the promotion of health and well-being, and in the training of health-care personnel. His work has been recognized through various Lifetime Achievements awards and other honors.