The American Society of Clinical Investigation (ASCI) presents the Stanley J. Korsmeyer Award to one or two scientists who have made substantial contributions to understanding of disease and to mentoring the next generation of physician-scientists each year. Originally named the ASCI Award, it was renamed in 2006 to honor the first recipient of the prize, Dr. Stanley J. Korsmeyer, a physician-scientist respected widely for both his impactful science and his own remarkable legacy of mentorship. To recognize the 25th Anniversary of the Korsmeyer Award, the Journal of Clinical Investigation is featuring a series of Review and Viewpoint articles from past Korsmeyer Award winners, which will published over the course of 2023.