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Lu, Min; Zak, Jaroslav; Chen, Shuo; Sanchez-Pulido, Luis; Severson, David T.; Endicott, Jane; Ponting, Chris P.; Schofield, Christopher J.; Lu, Xin
Cell, 05/2014, Letnik: 157, Številka: 5Journal Article
Regulation of nuclear import is fundamental to eukaryotic biology. The majority of nuclear import pathways are mediated by importin-cargo interactions. Yet not all nuclear proteins interact with importins, necessitating the identification of a general importin-independent nuclear import pathway. Here, we identify a code that determines importin-independent nuclear import of ankyrin repeats (ARs), a structural motif found in over 250 human proteins with diverse functions. AR-containing proteins (ARPs) with a hydrophobic residue at the 13th position of two consecutive ARs bind RanGDP efficiently, and consequently enter the nucleus. This code, experimentally tested in 17 ARPs, predicts the nuclear-cytoplasmic localization of over 150 annotated human ARPs with high accuracy and is acquired by the most common familial melanoma-associated CDKN2A mutation, leading to nuclear accumulation of mutant p16ink4a. The RaDAR (RanGDP/AR) pathway represents a general importin-independent nuclear import pathway and is frequently used by AR-containing transcriptional regulators, especially those regulating NF-κB/p53. Display omitted •RanGDP binding to ankyrin repeat (AR) defines the RaDAR nuclear import pathway•Hydrophobic 13th residues in ARs (AR13Hb) form a code for RanGDP binding•The most common familial melanoma CDKN2A mutation introduces the code into the p16•Presence of AR13Hb in two consecutive ARs predicts the nuclear localization of ARPs Ankyrin-repeat-containing proteins, including transcriptional regulators of NF-κB and p53, use patterned binding of RanGDP within their ankyrin repeats to regulate their nuclear localization independent of the importin pathway.
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