This paper examines the effect of the COVID-19 pandemic and its related economic, fiscal, social and political fallout on cities and metropolitan regions. We assess the effect of the pandemic on urban economic geography at the intra- and inter-regional geographic scales in the context of four main forces: the social scarring instilled by the pandemic; the lockdown as a forced experiment; the need to secure the urban built environment against future risks; and changes in the urban form and system. At the macrogeographic scale, we argue the pandemic is unlikely to significantly alter the winner-take-all economic geography and spatial inequality of the global city system. At the microgeographic scale, however, we suggest that it may bring about a series of short-term and some longer-running social changes in the structure and morphology of cities, suburbs and metropolitan regions. The durability and extent of these changes will depend on the timeline and length of the pandemic.