Abstract The study aims to investigate the effect of artemisia herba alba extract and ZnONPs on the level of lipid profile that included total cholesterol, triglycerides, low-density lipoproteins, and at the level of liver enzymes that included (AST, ALT, ALP) in adult rats Sprague-Dawley and lipoproteinosis. Rats were distributed to six aggregates in six repeaters each. (T1) Control Group, (T2) Nutritious Group on high cholesterol leeches, (T3) Nutritions high cholesterol food aggregates and soft cheese dosage (2 g/kg) (T4), ZnONPs 10mg/ml (T5) Artemisia herba alba (150/ml), (T6) Artemisia herba alba with ZnONPs. After the end of the feeding period for the vital experiment of 28 days. The Results showed a moral decrease (p≤0.05) in the rate of cholesterol, triglycerides and low-density lipoproteins in the T3, T4 group, T5, T6 compared with T1, while T2 treatment continued to rise in blood fat because it was left untreated. A moral decrease in the level of liver enzymes (AST, ALT, ALP) was also observed for animals treated with T3, T4, T5, T6 compared to T2, which was left untreated, with an increase in the concentration of liver enzymes.