Peroxisome‐proliferator activated receptor (PPARγ) plays a role in tumor growth inhibition and metabolic activity. Cinnamon extract components have been proposed as a possible PPARγ ligand and we sought to investigate if cinnamon treatment of cells affected the PPARγ and adiponectin expression. 3T3‐L1 cells were cinnamon treated for 72 and 120 hours. Media was collected for ELISA quantification of Adiponectin levels. Copy DNA was produced from the total RNA and expression levels of PPARγ and Adiponectin were examined by TaqMan real‐time PCR assays. Expression of PPARγ increases significantly in both post‐differentiated cells at 72 hours and in non‐differentiated cells at 120 hours. Expression of AdipoQ is increased in post‐differentiated cells significantly when compared to non‐differentiated cells. AdipoQ expression increases at 72 hours post differentiation. Post differentiation cells demonstrated high levels of adiponectin in the media. No significant difference was observed between the cinnamon treated cells and the vehicle control cells. Higher levels of PPARγ in the post‐differentiated cells correlate with the increase in adiponectin expression and adiponectin secreted in the post‐differentiation cells. A lag between the adipoQ expression increases at 72 hours post‐differentiation and adiponectin in the media was detected at high levels at 120 hours. Although there is no significant difference in the adiponectin in the media between vehicle samples and cinnamon treated samples, the expression data compares the control to the cinnamon treated cells, therefore the expression changes observed result from cinnamon treatment. This data suggests that perhaps a mechanism exists that stops adiponectin at the translation level.