The radiations emitted via 19F(α,nγ), 19F(α,pγ), and 19F(α,α′γ) reactions in compounds containing alpha-emitting elements and fluorine are used for non-destructive neutron and gamma-ray analyses in monitoring the contents of nuclear fissile materials during the manufacture, processing, and storage of nuclear fuels. As far as the literature survey confirms, the data available on the yield of (α,n) reaction on fluorine, which depends on alpha particle energy, have significant dispersion. For the accompanying gamma-rays, on the other hand, no reliable absolute data exist for the production yield of gamma-rays per number of interacting alpha particles or emitted nucleons as a function of alpha particle energy. Therefore, to improve the monitoring and control of nuclear materials and to ensure the safety of production processes, the present study was undertaken, where the neutron yields and energy spectra were calculated using the Nedis-2m program taking into account the updated values of the total cross-section for (α,n) reactions on 19F. The resulting Nedis-2m input datasets were used in the MCNP6 code to calculate the leakage multiplication factor and neutron energy spectrum. •The necessity of updated reference data for 19F(α,n)-reaction yield is confirmed.•Nedis2m with updated data refined neutron and gamma yields and energy spectra.•The results of the study improve controlling of nuclear materials.•The detection of fusion α particles can be improved by the results of this study.