Abstract Objective To compare the fatigue life and damage modes of zirconia crowns fabricated with and without framework design modification when porcelain veneered using a fast or slow cooling protocol. Methods Composite resin replicas of a first molar full crown preparation were fabricated. Zirconia copings were milled as conventional (0.5 mm even thickness, Zr-C, n = 20,) or modified (lingual margin of 1.0 mm thickness, 2.0 mm height connected to two proximal struts of 3.5 mm height, Zr-M, n = 20). These groups were subdivided ( n = 10 each) according to the veneer cooling protocol employed: fast cooling (Zr-CFast and Zr-MFast) and slow cooling (Zr-CSlow and Zr-MSlow). Crowns were cemented and fatigued for 106 cycles in water. The number of cycles to failure was recorded and used to determine the interval databased 2-parameter probability Weibull distribution parameter Beta ( β ) and characteristic life value Eta ( η ). Results 2-parameter Weibull calculation presented β = 5.53 and β = 4.38 for Zr-MFast and Zr-CFast, respectively. Slow cooled crowns did not fail by completion of 106 cycles, thereby Weibayes calculation was applied. Increased fatigue life was observed for slow cooled crowns compared to fast cooled ones. Groups Zr-MFast and Zr-MSlow presented no statistical difference. Porcelain cohesive fractures were mainly observed in fast cooled groups. Slow cooled crowns presented in some instances inner cone cracks not reaching the zirconia/veneer interface. Significance Improved fatigue life in tandem with the absence of porcelain fractures were observed in slow cooled crowns, regardless of framework design. Crowns fast cooled chiefly failed by porcelain cohesive fractures.