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Otoukesh, Babak; Abbasi, Mehdi; Gorgani, Habib-o-Lah; Farahini, Hossein; Moghtadaei, Mehdi; Boddouhi, Bahram; Kaghazian, Peyman; Hosseinzadeh, Shayan; Alaee, Atefe
Cancer cell international, 06/2020, Letnik: 20, Številka: 1Journal Article
Abstract MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted.
