This paper focuses on the development of a new computational model of the CNESTEN’s TRIGA Mark II researchreactor using the 3D continuous energy Monte-Carlo code TRIPOLI-4 (T4). This new model was developed toassess neutronic simulations and determine quantities of interest such as kinetic parameters of the reactor,control rods worth, power peaking factors and neutron flux distributions. This model is also a key tool used toaccurately design new experiments in the TRIGA reactor, to analyze these experiments and to carry out sensitivityand uncertainty studies. The geometry and materials data, as part of the MCNP reference model, were usedto build the T4 model. In this regard, the differences between the two models are mainly due to mathematicalapproaches of both codes. Indeed, the study presented in this article is divided into two parts: the first part dealswith the development and the validation of the T4 model. The results obtained with the T4 model were comparedto the existing MCNP reference model and to the experimental results from the Final Safety Analysis Report(FSAR). Different core configurations were investigated via simulations to test the computational model reliabilityin predicting the physical parameters of the reactor. As a fairly good agreement among the results wasdeduced, it seems reasonable to assume that the T4 model can accurately reproduce the MCNP calculated values.The second part of this study is devoted to the sensitivity and uncertainty (S/U) studies that were carried out toquantify the nuclear data uncertainty in the multiplication factor keff . For that purpose, the T4 model was used tocalculate the sensitivity profiles of the keff to the nuclear data. The integrated-sensitivities were compared to theresults obtained from the previous works that were carried out with MCNP and SCALE-6.2 simulation tools anddifferences of less than 5% were obtained for most of these quantities except for the C-graphite sensitivities.Moreover, the nuclear data uncertainties in the keff were derived using the COMAC-V2.1 covariance matriceslibrary and the calculated sensitivities. The results have shown that the total nuclear data uncertainty in the keff isaround 585 pcm using the COMAC-V2.1. This study also demonstrates that the contribution of zirconium isotopesto the nuclear data uncertainty in the keff is not negligible and should be taken into account when performingS/U analysis.