Introduction The 2019 Coronavirus disease epidemic is a public health emergency of international concern and poses a challenge to psychological resilience. Objectives To study the psychological repercussions in terms of anxiety and depression of the Coronavirus pandemic on the Tunisian population. Methods This was a cross-sectional, descriptive and analytical study. We used an online questionnaire on Facebook, on June 2020. The heteroquestionnaire included epidemiological data and two scales: the State-Trait Anxiety Inventory (STAI Form Y-1) to evaluate the anxiety level at the time of the study, and the Patient Health Questionnaire (PHQ 9) to detect a characterized depressive episode. Results We included 121 participants. They had an average age of 36.52 years with a sex ratio (M/F) of 0.41. The mean STAI score was 43.12 while the PHQ score was 7.46, indicating that 30.8% of the participants suffered from depression. Both scores were correlated to female sex (p=0.01 for STAI and p=0.02 for PHQ), a history of anxiety (p<0.001) and depressive disorders (p<0.001) and to poor sleep quality (p<0.001). The STAI score was also associated with a family history of high blood pressure (p=0.004), while the PHQ score was correlated to a family history of diabetes (p=0.02), a widowed or divorced marital status (p<0.001) and to a single lifestyle (p=0.03). Furthermore, the two scores (STAI-Y and PHQ 9) were also associated (p<0.001; r=0.67). Conclusions The psychological impact of Coronavirus epidemic seems not negligible requiring psychological interventions to improve the mental health of vulnerable groups.