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Salmena, Leonardo; Poliseno, Laura; Tay, Yvonne; Kats, Lev; Pandolfi, Pier Paolo
Cell, 08/2011, Letnik: 146, Številka: 3Journal Article
Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs “talk” to each other using microRNA response elements (MREs) as letters of a new language. We propose that this “competing endogenous RNA” (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
