The plugging phenomenon near the well zone of oil injection well will seriously affect the water injection development of oil field, and then affect the exploitation of oil resources. The water injection development of low permeability reservoir is affected by various factors. Due to the large difference between layers and the serious interference between layers, the physical property of oil layer is relatively poor, and the water injection pressure shows a trend of increasing year by year, which has a great impact on the development of oil resources. As the oilfield development benefit is not ideal, it is necessary to take reasonable measures to reduce the pressure of water injection to ensure the effect of water injection to improve the recovery of the reservoir. At present, the technology has been mature, which can reduce the pressure of water injection and ensure the oil recovery rate. The application in several oil Wells has verified the correctness of this conclusion.