The COVID-19 pandemic has had significant consequences for Americans' daily lives. Many people are spending more time in their homes due to work from home arrangements, stay at home orders, and closures of businesses and public gathering spaces. In this study, we explored how one's attachment to their home may help to buffer their mental health during this stressful time. Data were collected from a three-wave, longitudinal sampling (n=289) surveyed at baseline, two, and four weeks after. We found a clear relationship between an individual's attachment to home and positive mental health. Across all three waves, home attachment was negatively associated with symptoms of depression, anxiety, and stress. Furthermore, participants' home attachment at baseline was predictive of subsequent mental health two weeks after, which suggests that one's relationship to their home was particularly important during the initial onset of the national response to the outbreak. Predictors of home attachment included conscientiousness, agreeableness, and restorative ambience. Over the course of the study, kinship ambience also emerged as a predictor of home attachment. In the midst of increased mental health concerns and limited resources due to COVID-19, the home may buffer some individuals from depressive and anxiety-related symptoms by functioning as a source of refuge, security, and stability. •Study tests relationship between home attachment and mental health during pandemic.•Home attachment negatively associated with stress, anxiety, and depressive symptoms.•Attachment during the initial adjustment to COVID-19 was particularly important.•Home ambience of kinship became a stronger predictor of home attachment over time.