Background According to literature, the COVID-19 pandemic caused stressful working conditions for nurses, which may have a negative impact on their Well-Being and mental health. Aim To investigate whether nurses and non -helping professionals differ in their Well-Being. Furthermore, we analyzed, for the first time, which personality traits and styles are a risk factor for nurses’ wellbeing during COVID-19 pandemic. Methods In an online survey, the following psychological tests were used on nursing staff ( n = 518) and non -helping professionals ( n = 335): WHO-Five ( WHO-5 ), the Personality, Style and Disorder Inventory ( PSSI ), and the Freiburg Personality Inventory-Revised ( FPI-R ). Results Nurses and non -helping professionals did not differ significantly in terms of Well-Being. The Well-Being of nurses was correlated with the following personality traits and styles, namely Spontaneous-Borderline Personality Style , Silent-Depressive Personality Style , Strain , Emotionality , and Life Satisfaction . According to our results, 33% of participants suffered from clinically significant depressive symptoms. Discussion According to our results, nurses are not more at risk for depression. However, it was shown that Well-Being during the pandemic is highly dependent on personality. Conclusion Specific personality traits and styles are a greater predictor of depressive symptoms than profession. The stressful occupational environment during COVID-19 pandemic is not the only cause for depressive symptoms in nurses. Psychotherapeutic interventions are especially important for particular individuals and are necessary to prevent depressive symptoms during COVID-19 pandemic.