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Ludwig, Barbara; Ludwig, Stefan; Steffen, Anja; Knauf, Yvonne; Zimerman, Baruch; Heinke, Sophie; Lehmann, Susann; Schubert, Undine; Schmid, Janine; Bleyer, Martina; Schönmann, Uwe; Colton, Clark K.; Bonifacio, Ezio; Solimena, Michele; Reichel, Andreas; Schally, Andrew V.; Rotem, Avi; Barkai, Uriel; Grinberg-Rashi, Helena; Kaup, Franz-Josef; Avni, Yuval; Jones, Peter; Bornstein, Stefan R.
Proceedings of the National Academy of Sciences - PNAS, 10/2017, Letnik: 114, Številka: 44Journal Article
Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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