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Ishii, Kentaro K.; Osakada, Takuya; Mori, Hiromi; Miyasaka, Nobuhiko; Yoshihara, Yoshihiro; Miyamichi, Kazunari; Touhara, Kazushige
Neuron, 07/2017, Letnik: 95, Številka: 1Journal Article
In mice, various instinctive behaviors can be triggered by olfactory input. Despite growing knowledge of the brain regions involved in such behaviors, the organization of the neural circuits that convert olfactory input into stereotyped behavioral output remains poorly understood. Here, we mapped the neural circuit responsible for enhancing sexual receptivity of female mice by a male pheromone, exocrine gland-secreting peptide 1 (ESP1). We revealed specific neural types and pathways by which ESP1 information is conveyed from the peripheral receptive organ to the motor-regulating midbrain via the amygdala-hypothalamus axis. In the medial amygdala, a specific type of projection neurons gated ESP1 signals to the ventromedial hypothalamus (VMH) in a sex-dependent manner. In the dorsal VMH, which has been associated with defensive behaviors, a selective neural subpopulation discriminately mediated ESP1 information from a predator cue. Together, our data illuminate a labeled-line organization for controlling pheromone-mediated sexual behavioral output in female mice. •Sex pheromone information is sorted by the amygdala in a sexually dimorphic manner•A novel pathway from the hypothalamus to midbrain modulates female sexual behavior•Sex pheromone and predator cue signals are represented by mostly distinct neurons Ishii et al. show a labeled-line neural circuitry for a sex pheromone, ESP1, that controls sexual receptivity of female mice. This circuit relays information in a sexually dimorphic manner, which is in line with the sex-dependent effects of ESP1.
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