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Appel, Tobias Manuel; Stein, Claudia; Brandt, Christian; Rödel, Jürgen; Frietsch, Jochen J.; Miethke, Jenny; Hochhaus, Andreas; Hilgendorf, Inken
Infection, 08/2023, Letnik: 51, Številka: 4Journal Article
Metallo- β -lactamases (MBL) are a threat to public health, since they dramatically limit the use of β -lactams. We report the isolation of a multidrug-resistant Hafnia paralvei strain from urine and a rectal swab of a female patient after allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome. Antimicrobial susceptibility testing yielded resistance to trimethoprim/sulfamethoxazole, colistin, fosfomycin and all β -lactams, except cefiderocol. Whole genome sequencing revealed the presence of plasmid-encoded NDM-1 and VIM-1 carbapenemases. This finding highlights the importance of epidemiological surveillance and new therapeutic options for MBL.
