•A new cleanup material (EMR-Lipid) was evaluated in the analysis of food contaminants.•EMR-Lipid showed excellent lipid removal efficiency, and partial removal of chlorophyll.•To date, this is the first peer-reviewed publication on the use of EMR-Lipid.•Validation results were acceptable for most analytes in kale, avocado, salmon, and pork.•Matrix effects were relatively low using analyte protectants in fast GC–MS/MS. This study demonstrates the application of a novel lipid removal product to the residue analysis of 65 pesticides and 52 environmental contaminants in kale, pork, salmon, and avocado by fast, low pressure gas chromatography – tandem mass spectrometry (LPGC–MS/MS). Sample preparation involves QuEChERS extraction followed by use of EMR-Lipid (“enhanced matrix removal of lipids”) and an additional salting out step for cleanup. The optimal amount of EMR-Lipid was determined to be 500mg for 2.5mL extracts for most of the analytes. The co-extractive removal efficiency by the EMR-Lipid cleanup step was 83–98% for fatty samples and 79% for kale, including 76% removal of chlorophyll. Matrix effects were typically less than ±20%, in part because analyte protectants were used in the LPGC–MS/MS analysis. The recoveries of polycyclic aromatic hydrocarbons and diverse pesticides were mostly 70–120%, whereas recoveries of nonpolar polybrominated diphenyl ethers and polychlorinated biphenyls were mostly lower than 70% through the cleanup procedure. With the use of internal standards, method validation results showed that 76–85 of the 117 analytes achieved satisfactory results (recoveries of 70–120% and RSD≤20%) in pork, avocado, and kale, while 53 analytes had satisfactory results in salmon. Detection limits were 5–10ng/g for all but a few analytes. EMR-Lipid is a new sample preparation tool that serves as another useful option for cleanup in multiresidue analysis, particularly of fatty foods.