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Sheng, Tao; Zhang, Hai-Jun; Shang, Ming; He, Chi; Vantourout, Julien. C; Baran, Phil. S
Organic letters, 10/2020, Letnik: 22, Številka: 19Journal Article
An operationally simple method to employ nonactivated carboxylic acids as alkylating agents in the N-alkylation of heterocycles is reported through an electrochemically driven anodic decarboxylative process. A wide substrate scope across a range of heterocycles is demonstrated along with a series of applications that significantly reduce the step count required to access such medicinally relevant structures.
