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Kim, Young-Il; Yu, Kwang-Min; Koh, June-Young; Kim, Eun-Ha; Kim, Se-Mi; Kim, Eun Ji; Casel, Mark Anthony B; Rollon, Rare; Jang, Seung-Gyu; Song, Min-Suk; Park, Su-Jin; Jeong, Hye Won; Kim, Eung-Gook; Lee, Ok-Jun; Kim, Yong-Dae; Choi, Younho; Lee, Shin-Ae; Choi, Youn Jung; Park, Su-Hyung; Jung, Jae U; Choi, Young Ki
Nature communications, 01/2022, Letnik: 13, Številka: 1Journal Article
While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individuals. To further understand differing COVID-19 manifestations in patients of different ages, three age groups of ferrets are infected with SARS-CoV-2. Although SARS-CoV-2 is isolated from all ferrets regardless of age, aged ferrets (≥3 years old) show higher viral loads, longer nasal virus shedding, and more severe lung inflammatory cell infiltration, and clinical symptoms compared to juvenile (≤6 months) and young adult (1-2 years) groups. Furthermore, direct contact ferrets co-housed with the virus-infected aged group shed more virus than direct-contact ferrets co-housed with virus-infected juvenile or young adult ferrets. Transcriptome analysis of aged ferret lungs reveals strong enrichment of gene sets related to type I interferon, activated T cells, and M1 macrophage responses, mimicking the gene expression profile of severe COVID-19 patients. Thus, SARS-CoV-2-infected aged ferrets highly recapitulate COVID-19 patients with severe symptoms and are useful for understanding age-associated infection, transmission, and pathogenesis of SARS-CoV-2.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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