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Jung, Kwonil; Hu, Hui; Saif, Linda J.
Archives of virology, 08/2017, Letnik: 162, Številka: 8Journal Article
Fecal virus shedding, seroconversion and histopathology were evaluated in 3-7-year-old gnotobiotic calves orally inoculated with porcine deltacoronavirus (PDCoV) (9.0-9.6 log 10 genomic equivalents GE of OH-FD22-P5; n =4) or porcine epidemic diarrhea virus (PEDV) (10.2-12.5 log 10 GE of PC21A; n =3). In PDCoV-inoculated calves, an acute but persisting fecal viral RNA shedding and PDCoV-specific serum IgG antibody responses were observed, but without lesions or clinical disease. However, no fecal shedding, seroconversion, histological lesions, and clinical disease were detected in PEDV-inoculated calves. Our data indicate that calves are susceptible to infection by the newly emerged PDCoV, but not by the swine coronavirus, PEDV.
