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Lee, Ju Hee; Ealey, Kafi N.; Patel, Yash; Verma, Navkiran; Thakkar, Nikita; Park, So Young; Kim, Jae-Ryong; Sung, Hoon-Ki
iScience, 04/2022, Letnik: 25, Številka: 4Journal Article
The increased prevalence of obesity and metabolic diseases has heightened interest in adipose tissue biology and its potential as a therapeutic target. To better understand cellular heterogeneity and complexity of white adipose tissue (WAT), we employed cytometry by time-of-flight (CyTOF) to characterize immune and stromal cells in visceral and subcutaneous WAT depots under normal and high-fat diet feeding, by quantifying the expression levels of 32 surface marker proteins. We observed comparable proportions of immune cells in two WAT depots under steady state, but depot-distinct subtypes of adipose precursor cells (APC), suggesting differences in their adipogenic and fibrogenic potential. Furthermore, in addition to pro-inflammatory immune cell shifts, significant pro-fibrotic changes were observed in APCs under high-fat diet, suggesting that APCs are early responders to dietary challenges. We propose CyTOF as a complementary and alternative tool to current high-throughput single-cell transcriptomic analyses to better understand the function and plasticity of adipose tissue. Display omitted •Application of CyTOF for cellular characterization in two adipose depots•Adipose depot-distinct APC subpopulations•APCs are early responders under obesogenic conditions to regulate WAT fibrosis Immunology; Cell biology; Specialized functions of cells
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