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Yazdani, Solmaz; Seitz, Christina; Cui, Can; Lovik, Anikó; Pan, Lu; Piehl, Fredrik; Pawitan, Yudi; Kläppe, Ulf; Press, Rayomand; Samuelsson, Kristin; Yin, Li; Vu, Trung Nghia; Joly, Anne-Laure; Westerberg, Lisa S; Evertsson, Björn; Ingre, Caroline; Andersson, John; Fang, Fang
Nature communications, 11/2022, Letnik: 13, Številka: 1Journal Article
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving neuroinflammation and T cell infiltration in the central nervous system. However, the contribution of T cell responses to the pathology of the disease is not fully understood. Here we show, by flow cytometric analysis of blood and cerebrospinal fluid (CSF) samples of a cohort of 89 newly diagnosed ALS patients in Stockholm, Sweden, that T cell phenotypes at the time of diagnosis are good predictors of disease outcome. High frequency of CD4 FOXP3 effector T cells in blood and CSF is associated with poor survival, whereas high frequency of activated regulatory T (Treg) cells and high ratio between activated and resting Treg cells in blood are associated with better survival. Besides survival, phenotypic profiling of T cells could also predict disease progression rate. Single cell transcriptomics analysis of CSF samples shows clonally expanded CD4 and CD8 T cells in CSF, with characteristic gene expression patterns. In summary, T cell responses associate with and likely contribute to disease progression in ALS, supporting modulation of adaptive immunity as a viable therapeutic option.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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