E-viri
Recenzirano
Odprti dostop
-
Wagner, Mirko; Steinbacher, Jessica; Kraus, Theo F. J.; Michalakis, Stylianos; Hackner, Benjamin; Pfaffeneder, Toni; Perera, Arshan; Müller, Markus; Giese, Armin; Kretzschmar, Hans A.; Carell, Thomas
Angewandte Chemie (International ed.), October 12, 2015, Letnik: 54, Številka: 42Journal Article
The absolute levels of 5‐hydroxymethylcytosine (hmC) and 5‐methylcytosine (mC) in human brain tissues at various ages were determined. Additionally, absolute levels of 5‐formylcytosine (fC) in adult individuals and cytosine modification levels in sorted neurons were quantified. These data were compared with age‐related fC, hmC, and mC levels in mouse brain samples. For hmC, an initial steady increase is observed, which levels off with age to a final steady‐state value of 1.2 % in human brain tissue. This level is nearly twice as high as in mouse cerebral cortex. In contrast, fC declines rapidly with age during early developmental stages, thus suggesting that while hmC is a stable epigenetic mark, fC is more likely an intermediate of active DNA demethylation during early brain development. The trends in global cytosine modification dynamics during the lifespan of an organism are conserved between humans and mice and show similar patterns in different organs. Brain teaser: Age‐dependent global levels of 5‐methyl‐ (mC), 5‐hydroxymethyl‐ (hmC), and 5‐formylcytosine (fC) were quantified in human and mouse brain tissues. While the hmC content increases sharply with age to reach a high steady‐state level of 1.2 % in the adult human brain, fC levels rapidly decline during early developmental stages.
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.