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  • Modulatory mechanisms contr...
    Haneklaus, Moritz; O’Neill, Luke AJ; Coll, Rebecca C

    Current opinion in immunology, 02/2013, Letnik: 25, Številka: 1
    Journal Article

    Highlights ► Overview of the control of NLRP3 activity by the cellular redox environment. ► miRNA-223 and viral factors can inhibit NLRP3. ► Kinase and calcium signalling are emerging as regulators of NLRP3 activation. ► Outline of recent findings on ubiquitination and the mechanism of NLRP3 priming. ► Discussion of pharmacological manipulation of NLRP3 inflammasome activity.