E-viri
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Zhu, Guanhua; Guo, Yu A; Ho, Danliang; Poon, Polly; Poh, Zhong Wee; Wong, Pui Mun; Gan, Anna; Chang, Mei Mei; Kleftogiannis, Dimitrios; Lau, Yi Ting; Tay, Brenda; Lim, Wan Jun; Chua, Clarinda; Tan, Tira J; Koo, Si-Lin; Chong, Dawn Q; Yap, Yoon Sim; Tan, Iain; Ng, Sarah; Skanderup, Anders J
Nature communications, 04/2021, Letnik: 12, Številka: 1Journal Article
Profiling of circulating tumor DNA (ctDNA) may offer a non-invasive approach to monitor disease progression. Here, we develop a quantitative method, exploiting local tissue-specific cell-free DNA (cfDNA) degradation patterns, that accurately estimates ctDNA burden independent of genomic aberrations. Nucleosome-dependent cfDNA degradation at promoters and first exon-intron junctions is strongly associated with differential transcriptional activity in tumors and blood. A quantitative model, based on just 6 regulatory regions, could accurately predict ctDNA levels in colorectal cancer patients. Strikingly, a model restricted to blood-specific regulatory regions could predict ctDNA levels across both colorectal and breast cancer patients. Using compact targeted sequencing (<25 kb) of predictive regions, we demonstrate how the approach could enable quantitative low-cost tracking of ctDNA dynamics and disease progression.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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