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Zargar-Shoshtari, Kamran; Spiess, Philippe E; Berglund, Anders E; Sharma, Pranav; Powsang, Julio M; Giuliano, Anna; Magliocco, Anthony M; Dhillon, Jasreman
Clinical genitourinary cancer, August 2016, Letnik: 14, Številka: 4Journal Article
Micro-Abstract There is strong, but not complete, concordance between immunohistochemical stains for p16ink4a and human papilloma virus in situ hybridization. Warty, basaloid, or mixed warty basaloid tumor subtypes are significantly more common in p16ink4a -positive patients. In p16ink4a -negative patients, positive p53 status is associated with nodal metastasis (pN+). In pN+ patients, cancer-specific survival (CSS) was significantly worse in patients with negative p16ink4a and p53 expression. p16ink4a status is a significant predictor for improved CSS.
