Common Genetic Polymorphisms and Haplotypes of Fibrinogen Alpha, Beta, and Gamma Chains Affect Fibrinogen Levels and the Response to Proinflammatory Stimulation in Myocardial Infarction Survivors: The AIRGENE Study Bénédicte Jacquemin, Charalambos Antoniades, Fredrik Nyberg, Estel Plana, Martina Müller, Sonja Greven, Veikko Salomaa, Jordi Sunyer, Tom Bellander, Alexandros-Georgios Chalamandaris, Ricardo Pistelli, Wolfgang Koenig, Annette Peters We investigated whether single nucleotide polymorphisms (SNPs) and haplotypes of the fibrinogen gene-cluster (fibrinogen chain alpha FGA, beta FGB, and gamma FGG) could affect plasma levels of fibrinogen in patients with history of myocardial infarction (MI). We analyzed 21 SNPs and the corresponding haplotypes in the 3 genes. We identified several haplotypes and SNPs on the FGA/FGB genes that contributed to explain the interindividual and intraindividual variability of fibrinogen levels, in patients with a history of MI. We have also identified SNPs/haplotypes on FGA/FGB whose effects on fibrinogen expression are modified by the underlying interleukin-6 levels. These findings may be important for risk stratification of patients after MI and may be useful for the design of genetically guided therapeutic approaches in these patients.