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Fonken, Laura K; Frank, Matthew G; Kitt, Meagan M; Barrientos, Ruth M; Watkins, Linda R; Maier, Steven F
Brain, behavior, and immunity, 03/2015, Letnik: 45Journal Article
Highlights • There are temporal differences in sickness behavior in rats. • Changes in sickness behavior are reflected in hippocampal cytokine and microglial responses. • Microglia show dramatic differences in immune activation throughout the day, with peak activation during the light phase. • Microglia rhythms are entrained by, but oscillate independent of, glucocorticoids. • These results suggest time-of-day should be considered when planning procedures that induce neuroinflammation.
