E-viri
Recenzirano
Odprti dostop
-
Lasagni, Laura; Angelotti, Maria Lucia; Ronconi, Elisa; Lombardi, Duccio; Nardi, Sara; Peired, Anna; Becherucci, Francesca; Mazzinghi, Benedetta; Sisti, Alessandro; Romoli, Simone; Burger, Alexa; Schaefer, Beat; Buccoliero, Annamaria; Lazzeri, Elena; Romagnani, Paola
Stem cell reports, 08/2015, Letnik: 5, Številka: 2Journal Article
Podocyte loss is a general mechanism of glomerular dysfunction that initiates and drives the progression of chronic kidney disease, which affects 10% of the world population. Here, we evaluate whether the regenerative response to podocyte injury influences chronic kidney disease outcome. In models of focal segmental glomerulosclerosis performed in inducible transgenic mice where podocytes are tagged, remission or progression of disease was determined by the amount of regenerated podocytes. When the same model was established in inducible transgenic mice where renal progenitors are tagged, the disease remitted if renal progenitors successfully differentiated into podocytes, while it persisted if differentiation was ineffective, resulting in glomerulosclerosis. Treatment with BIO, a GSK3s inhibitor, significantly increased disease remission by enhancing renal progenitor sensitivity to the differentiation effect of endogenous retinoic acid. These results establish renal progenitors as critical determinants of glomerular disease outcome and a pharmacological enhancement of their differentiation as a possible therapeutic strategy. Display omitted •Renal progenitors can generate differentiated podocytes after glomerular injury•Renal progenitor response critically determines glomerular disease remission•Inefficient renal progenitor to podocyte differentiation dictates disease chronicization•Renal progenitor differentiation into podocytes can be enhanced with drugs In this article, Romagnani, Lasagni, and colleagues show that podocyte regeneration is a critical determinant of the outcome of glomerular disorders and that enhancement of renal progenitor differentiation into podocyte through pharmacological treatment shifts the disease from progression to remission.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.