E-viri
Recenzirano
Odprti dostop
-
Wang, Yaming; Bugatti, Mattia; Ulland, Tyler K.; Vermi, William; Gilfillan, Susan; Colonna, Marco
European Journal of Immunology, March 2016, Letnik: 46, Številka: 3Journal Article
IL‐34 and colony‐stimulating factor 1 (CSF1) are two alternative ligands for the CSF1 receptor that play nonredundant roles in the development, survival, and function of tissue macrophages and Langerhans cells (LCs). In this study, we investigated the spatio‐temporal production of IL‐34 and its impact on skin LCs in the developing embryo and adult mice in the steady state and during inflammation using Il34LacZ reporter mice and newly generated inducible Il34‐knockout mice. We found that IL‐34 is produced in the developing skin epidermis of the embryo, where it promotes the final differentiation of LC precursors. In adult life, LCs required IL‐34 to continually self‐renew in the steady state. However, during UV‐induced skin damage, LC regeneration depended on neutrophils infiltrating the skin, which produced large amounts of CSF1. We conclude that LCs require IL‐34 when residing in fully differentiated and anatomically intact skin epidermis, but rely on neutrophil‐derived CSF1 during inflammation. Our demonstration that neutrophils are an important source of CSF1 during skin inflammation may exemplify a mechanism through which neutrophils promote their subsequent replacement with mononuclear phagocytes. Nonredundant functions of IL‐34 and CSF1 in Langerhans cells (LCs) renewal. In a fully differentiated and anatomically intact skin epidermis, keratinocytes produce IL‐34 to sustain the steady‐state renewal of LCs residing in the skin. In UV‐irradiated and inflamed skin, LC regeneration depends on CSF1 produced by infiltrating neutrophils.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.