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Jorge Huerta, Lucía; Solares Fernández, Isabel; Sánchez‐Moreno, Beatriz; Males Maldonado, David; Ibarrola Andrés, Carolina; Díaz‐Simón, Raquel
Journal of digestive diseases, August‐September 2022, Letnik: 23, Številka: 8-9Journal Article
Objectives Non‐functioning gastrin‐producing neuroendocrine neoplasms (NEN) of the duodenum are rare gastrointestinal tumors without a clinical syndrome due to gastrin production. Their incidence has significantly increased as an incidental finding during endoscopic studies. The aim of this study was to describe the characteristics and prognostic factors of this emergent and infrequent neoplasm. Methods We performed a retrospective observational study based on the duodenal NENs samples with positive staining for gastrin at the Department of Pathology, University Hospital 12‐de‐Octubre (Madrid, Spain) between 2000 and 2017. Patients with clinically functional tumors (Zollinger–Ellison syndrome or gastrin >1000 pg/mL), with previously diagnosed multiple endocrine neoplasia (MEN) syndrome or synchronous neoplasia were excluded. Clinicopathological and therapeutic variables, follow‐up, recurrence, and mortality data were collected. Results In all, 21 patients were included. Most of the tumors were diagnosed incidentally as a single small polypoid lesion limited to mucosa/submucosa and with a low histological grade. Four (19.0%) patients presented with metastatic involvement at diagnosis (lymphatic and/or hepatic). These four patients also had a high or intermediate mitotic grade and infiltration further than submucosa. Local resection was applied in most cases as curative treatment. There were two cases of tumor recurrence and two tumor‐related deaths with a 5‐year disease‐free survival of 81.0%. Conclusions The majority of these tumors were diagnosed at a localized stage and had a good prognosis with treatment. Nevertheless, given the potential metastatic risk, a close follow‐up is necessary, especially in those with aggressive pathological factors such as deep infiltration or high histological grade. Neuroendocrine neoplasms (NEN) of the duodenum are rare tumors of the gastrointestinal tract. Their incidence has significantly increased in the last few years, mainly due to the availability of endoscopic studies. Non‐functioning gastrin‐producing tumors are most frequent and they are usually an incidental finding in clinical practice because of the absence of a clinical syndrome due to hormonal production. This study reviews one of the largest case series of non‐functioning gastrin‐producing duodenal NENs, including the most frequent clinical presentations, optimal management, and the common prognosis with 5‐year overall survival.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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