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Velazquez-Torres, Guermarie; Shoshan, Einav; Ivan, Cristina; Huang, Li; Fuentes-Mattei, Enrique; Paret, Harrison; Kim, Sun Jin; Rodriguez-Aguayo, Cristian; Xie, Victoria; Brooks, Denise; Jones, Steven J M; Robertson, A Gordon; Calin, George; Lopez-Berenstein, Gabriel; Sood, Anil; Bar-Eli, Menashe
Nature communications, 01/2018, Letnik: 9, Številka: 1Journal Article
Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. The effects of A-to-I miRNAs editing on melanoma growth and metastasis are yet to be determined. Here we report that miR-378a-3p is undergoing A-to-I editing only in the non-metastatic but not in metastatic melanoma cells. The function of the edited form is different from its wild-type counterpart. The edited form of miR-378a-3p preferentially binds to the 3'-UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype. Indeed, edited miR-378a-3p but not its WT form inhibits melanoma metastasis in vivo. These results further emphasize the role of RNA editing in melanoma progression.
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