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Recenzirano
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Dibchak, Dmitry; Snisarenko, Mariya; Mishuk, Artem; Shablykin, Oleh; Bortnichuk, Lina; Oleksii Klymenko‐Ulianov; Kheylik, Yurii; Sadkova, Iryna V; Rzepa, Henry S; Mykhailiuk, Pavel K
Angewandte Chemie International Edition, 09/2023, Letnik: 62, Številka: 39Journal Article
A general approach to 3‐azabicyclo3.1.1heptanes by reduction of spirocyclic oxetanyl nitriles was developed. The mechanism, scope, and scalability of this transformation were studied. The core was incorporated into the structure of the antihistamine drug Rupatidine instead of the pyridine ring, which led to a dramatic improvement in physicochemical properties.Dedicated to the people of Ukraine
