Bonnie et al comment on the new report, The Promise of Adolescence: Realizing Opportunity for All Youth, released in May 2019, is particularly timely. Today's youth, representing approximately 25% of the US population, are more culturally and ethnically diverse than ever before. Unfortunately, however, inequalities in income, access to resources, and opportunity among youth continue to increase, with stark differences in poverty by race, ethnic group, and geography. The report highlights two overarching messages. The first is that adolescence is a period of extraordinary opportunity for learning and exploration and for laying a strong foundation for a successful life. The second message is that our nation needs to commit itself to a sustained plan for reversing the worsening inequities of childhood disadvantage, thereby enabling all adolescents to flourish.