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Jochmans, I.; Moers, C.; Smits, J. M.; Leuvenink, H. G. D.; Treckmann, J.; Paul, A.; Rahmel, A.; Squifflet, J‐P.; van Heurn, E.; Monbaliu, D.; Ploeg, R. J.; Pirenne, J.
American journal of transplantation, October 2011, Letnik: 11, Številka: 10Journal Article, Web Resource
Vascular renal resistance (RR) during hypothermic machine perfusion (HMP) is frequently used in kidney graft quality assessment. However, the association between RR and outcome has never been prospectively validated. Prospectively collected RR values of 302 machine‐perfused deceased donor kidneys of all types (standard and extended criteria donor kidneys and kidneys donated after cardiac death), transplanted without prior knowledge of these RR values, were studied. In this cohort, we determined the association between RR and delayed graft function (DGF) and 1‐year graft survival. The RR (mmHg/mL/min) at the end of HMP was an independent risk factor for DGF (odds ratio 21.12 1.03–435.0; p = 0.048) but the predictive value of RR was low, reflected by a c‐statistic of the receiver operator characteristic curve of 0.58. The RR was also found to be an independent risk factor for 1‐year graft failure (hazard ratio 12.33 1.11–136.85; p = 0.004). Determinants of transplant outcome are multifactorial in nature and this study identifies RR as an additional parameter to take into account when evaluating graft quality and estimating the likelihood of successful outcome. However, RR as a stand‐alone quality assessment tool cannot be used to predict outcome with sufficient precision. Increased renal resistance during hypothermic machine perfusion of deceased donor kidneys associates with the development of delayed graft function and 1‐year graft survival, but cannot be used exclusively in the process of accepting a kidney graft.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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