Mechanical behaviour of the soil–structure interface plays a major role in the shear characteristics and bearing capacity of foundations. In thermoactive structures, due to nonisothermal conditions, the interface behaviour becomes more complex. The objective of this study is to investigate the effects of temperature variations on the mechanical behaviour of soils and the soil–structure interface. Constant normal load (CNL) and constant normal stiffness (CNS) tests were performed on the soil and soil–structure interface in a direct shear device at temperatures of 5, 22, and 60 °C. Fontainebleau sand and kaolin clay were used as proxies for sandy and clayey soils. The sandy soil was prepared in a dense state and the clayey soil was prepared in a normally consolidated state. Results show that the applied thermal variations have a negligible effect on the shear strength of the sand and sand–structure interface under CNL and CNS conditions, and the soil and soil–structure interface behaviour could be considered thermally independent. In clay samples, an increase in the temperature increased the cohesion and consequently the shear strength, due to thermal contraction during heating. The temperature rise had less impact on the shear strength in the case of the clay–structure interface than in the clay samples. The adhesion of the clay–structure interface is less than the cohesion of the clay samples.