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Simeonova, Rumyana; Vitcheva, Vessela; Gorneva, Galina; Mitcheva, Mitka
Arhiv za higijenu rada i toksikologiju, 03/2012, Letnik: 63, Številka: 1Journal Article
Myosmine 3-(1-pyrrolin-2-yl) pyridine is an alkaloid structurally similar to nicotine, which is known to induce oxidative stress. In this study we investigated the effects of myosmine on enzymatic and non-enzymatic antioxidative defence in rat liver. Wistar rats received a single injection of 19 mg kg of myosmine and an oral dose of 190 mg kg by gavage. Nicotine was used as a positive control. Through either route of administration, myosmine altered the hepatic function by decreasing the levels of reduced glutathione, superoxide dismutase, and glutathione peroxidase activities on one hand and by increasing malondialdehyde, catalase, and glutathione reductase activity on the other. Compared to control, both routes caused significant lipid peroxidation in the liver and altered hepatic enzymatic and non-enzymatic antioxidative defences. The pro-oxidant effects of myosmine were comparable with those of nicotine.
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